Texas A&M advances global disease prevention with launch of field-to-clinic initiative

By Blair Williamson

As the next step in a series of advancements to transform scientific discovery across Texas A&M University and, in turn, the state and nation, the Texas A&M Health Science Center (TAMHSC) Institute of Biosciences and Technology (IBT) in Houston is establishing a new Center for Epigenetics & Disease Prevention (CEDP) with support from the Chancellor’s Research Initiative (CRI).

The CEDP, with collaborators from across The Texas A&M University System, is poised to transform health care by shifting the standard model of disease prevention through an innovative “field-to-clinic” initiative. This new era of preventive medicine will integrate nutrition, chemistry and medicine to radically change the approach to cancer, metabolic disorders like diabetes and chronic conditions like cardiovascular disease. In short, researchers are focused on developing preventive treatments and pharmaceutical agents using beneficial compounds naturally found in food.

“This initiative brings together the A&M System’s best and brightest researchers, with expertise in agriculture, nutrition and medicine to form a diverse and highly collaborative team intent on developing revolutionary disease prevention solutions that will impact generations to come,” said John Sharp, chancellor of The Texas A&M University System.

Roderick H. Dashwood will become the new leader of the Center for Epigenetics & Disease Prevention.

A multidisciplinary and cross-institutional team is spearheading the novel field-to-clinic approach aimed at identifying phytochemicals, or naturally-occurring plant compounds, in whole foods that inhibit disease or have other preventive qualities beneficial to humans and animals. Once identified, such compounds will undergo quality-controlled, large-scale production in preparation for human clinical trials. To accomplish this, the CRI has invested $9 million in the field-to-clinic enterprise, including funds to recruit new faculty members and to create interdisciplinary ties across the system, including Texas A&M AgriLife Research.

“Such collaborations reinforce our commitment to the One Health initiative, which emphasizes the link between humans, animals and plants,” said R. Bowen Loftin, Ph.D., president of Texas A&M University. “The opportunities currently in place across the university and system make this the right time for Texas A&M to establish itself as a world leader working at the interface of diet, epigenetics and disease prevention.”

To lead the CEDP, the IBT has recruited Roderick H. Dashwood, Ph.D., a world-renowned expert in dietary cancer prevention and epigenetics – a research field that investigates alterations in gene expression caused by mechanisms other than changes in DNA sequence. He comes to TAMHSC from the Linus Pauling Institute at Oregon State University where he served as director of the Cancer Chemoprotection Program. He also will hold a faculty appointment with Texas A&M AgriLife Research, with an adjunct appointment in the Department of Clinical Cancer Prevention at MD Anderson Cancer Center.

“The addition of Dr. Dashwood to the preeminent team of scientists across Texas A&M and partnering entities in the Texas Medical Center in Houston positions the Texas A&M Institute for Biosciences and Technology to be a global frontrunner in disease prevention,” said Brett P. Giroir, M.D., who currently serves as vice chancellor for strategic initiatives for the Texas A&M System and will assume the role of interim executive vice president of TAMHSC on Oct. 1.

Dashwood will oversee efforts to initially isolate beneficial compounds and then formulate them with the help of the National Center for Therapeutics Manufacturing (NCTM) so that they can be administered in the type of controlled method necessary for clinical trials. Researchers from the College of Agriculture and Life Sciences and the College of Science will help separate and synthesize derivatives of beneficial phytochemicals. Preclinical animal model studies will then be performed in collaboration with researchers at the College of Veterinary Medicine and Biomedical Sciences. They will work with the Texas Institute for Preclinical Studies (TIPS) to screen these compounds in naturally occurring and genetically engineered mice supplied by the Texas Institute for Genomic Medicine (TIGM).

Researchers will use the Gulf Coast Consortium for Chemical Genomics screening center at the IBT comprised of high-throughput robotic workstations to evaluate the compounds and look for new “hits” for cancer prevention. The majority of the workstations in this screening center were funded by a $12 million grant from the Cancer Prevention Research Institute of Texas awarded to Pete Davies, M.D., Ph.D., director of IBT’s Center for Translational Cancer Research and IBT associate director. Texas A&M also invested an additional $1 million for an additional workstation to study other non-cancer diseases.

“At the IBT, we now can start screening natural compounds for their ability to kill cancer cells and probe for epigenetic changes that cut across multiple diseases and chronic conditions beyond cancer.  This is what makes epigenetics such an exciting area,” Dashwood said. “There is good evidence that natural compounds acting via epigenetic mechanisms will prove beneficial in preventing and treating many diseases. Our initial focus will be on cancer prevention at the earliest stages of the disease, but we have an eye on transitioning our research into conditions such as chronic obstructive pulmonary disease (COPD), neurological disorders and specific childhood illnesses.”

Once identified, the best compounds will then go to the Texas Medical Center for testing in human clinical trials.

“Recruitment of Dr. Dashwood will connect the research activities across the state in new and exciting ways,” said Cheryl Walker, Ph.D., director of the IBT. “Scientific advances in nutrition, agriculture and chemistry that are being made in College Station now will be rapidly translated into clinical trials in the Texas Medical Center to prevent cancer and many other diseases.”

While the IBT will house Dashwood and the new center, significant contributions to this enterprise come from across the A&M System, including Texas A&M University System Office of the Chancellor; Texas A&M University Office of the Provost and Vice President for Research; Texas A&M Health Science Center and its College of Medicine; College of Veterinary Medicine and Biomedical Sciences; College of Science; College of Agriculture and Life Sciences; and Texas A&M AgriLife Research.

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6th International Human Health Effects of Fruits & Vegetables Symposium

Information regarding the 6th International Human Health Effects of Fruits & Vegetables Symposium (FAVHealth 2014) is now available. For information regarding the conference, dates, speakers, accommodations, and more, please click the following link: FAVHealth 2014

Bhimu Patil gets Distinguished Service Award from American Chemical Society

Dr. Patil

Dr. PatilStory by: Kathleen Phillips

COLLEGE STATION — Dr. Bhimu Patil, director of the Texas A&M University Vegetable and Fruit Improvement Center, has received the Distinguished Service Award from the American Chemical Society’s Division of Agriculture and Food Chemistry.

The award was presented Sept. 10 at the society’s annual meeting in Indianapolis, Ind.

Patil has been a leader in the society’s agriculture and food chemistry division for years and was chair of the 3,100-member division in 2007. He received the Outstanding Young Scientist award  in 2003 and was selected as fellow of the division in 2009.

“Dr. Patil is most deserving of this award. He has served selflessly and has been responsible for organizing high-quality, well-attended symposia on fruit and vegetable bioactives for the division,” said Dr. Lauren Jackson, U.S. Food and Drug Administration official and member of the division. “He also has been essential in recruitment of young scientists as active members to our division, which ensures the continued path of producing excellent scientific programs.”

Patil, a native of Dambal, India, has received numerous awards in his career, including the Outstanding Graduate Education Award earlier this year by the American Society for Horticultural Sciences and the Texas A&M University’s College of Agriculture and Life Science Dean’s Outstanding Achievement Award for Research. He also received his nation’s Karnataka Rajyotsava award.

He is internationally known for his research and leadership on bioactive compounds in fruits and vegetables.

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Jayaprakasha named American Chemical Society Fellow

Dr. Jayaprakasha

Dr. JayaprakashaCOLLEGE STATION — Dr. G.K. Jayaprakasha, a researcher at Texas A&M AgriLife’s Vegetable and Fruit Improvement Center and department of horticultural sciences in College Station, has been selected a Fellow in the American Chemical Society’s Division of Agriculture and Food Chemistry.

Jayaprakasha will receive the honor at the society’s annual meeting Sept. 8-12 in Indianapolis.

According to the citation, his collaborative work has been published in more than 105 peer-reviewed food science and technology, analytical, bio-organic and medical chemistry journals. He has edited and authored several books, reviews and chapters and presented at almost 160 national and international symposiums.

He is known for developing a novel process for the isolation of bioactives from natural sources such as fruits and vegetables, mainly from citrus juice, and has filed 24 patents in the U.S., Europe and India.

Jayaprakasha also recently was recognized by the Royal Society of Chemistry in London  as a Fellow of Royal Society of Chemistry, received the Laljee Godhoo Smark Nidhi award by the Association of Food Scientists and Technologists of India and was recognized as a Fellow of Indian Chemists by the Institution of Chemists in India.

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Patil honored as outstanding graduate educator by American horticultural society

oustanidng grad_ASHS Award2013_largeStory by: Kathleen Phillips

PALM SPRINGS, Calif. – The American Society for Horticultural Science has presented Dr. Bhimu Patil of College Station its Outstanding Graduate Education Award.

        The award was presented July 22 during the society’s annual conference in Palm Springs, Calif.

        Patil, who is director of the Texas A&M University Vegetable and Fruit Improvement Center, was given the award in recognition as “an educator who has had a distinguished and outstanding graduate education teaching career in horticultural science for a period of 10 or more years,” according to Michael W. Neff of Alexandria, Va., executive director of the horticultural society.

        “Dr. Patil is recognized as a leader in the foods for health agenda, both nationally and internationally,” Neff said. “He runs a large and very productive research program focused on the study of human-health related plant secondary metabolites. Patil has mentored more than 26 graduate students in his career. His students have all followed his example by exhibiting an eager pursuit of plant bioactive research and publishing their research in appropriate journals.”

        Neff further cited Patil’s passion and commitment to teaching and learning.

        “He has dedicated tremendous effort toward the development and implementation of two novel graduate courses at Texas A&M and five other universities simultaneously,” Neff added. “He strives to provide students an understanding of his research information so that they can become role models and teach others.”

        The society further noted that Patil’s interest in training students in interdisciplinary sciences “is evident from his students’ publication records and their employment in leading research centers and in professional careers.”

Patil is also professor of horticultural sciences at Texas A&M.

“Dr. Patil uses research as an educational tool rather than just an activity of its own. This is demonstrated through his successful students and the numerous courses, curricula and educational programs he has developed,” said Dr. Alan Sams, executive associate dean for the College of Agriculture and Life Sciences at Texas A&M.

        Patil has served as a chair or co-chair for 26 graduate students and on six student committees. His former students are now serving in several universities, medical institutions, federal agencies and in industry.

        “His guidance as an outstanding scientist has also inspired some undergraduate students to continue their education and achieve advanced degrees. He displays a very optimistic attitude in all aspects of his teaching and interaction with students. Patil’s vision is that students can always do better than they first expect with encouragement and guidance, and he is dedicated to teaching and mentoring students to achieve their full potential,” Neff said.

        In 2009, Patil was named a Fellow of the horticultural society, a Fellow of the Food Chemistry Division of the American Chemical Society and a Texas A&M AgriLife Fellow.

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Student workers value jobs in research more after national competition

Student workers at the Texa A&M University Vegetable and Fruit Improvement Center for 2013 are (from the left, back row) Jose Perez, Michael Harris, Dennis Vandenberge, and (from the left, front row) Akshata Kulkarni, Natacha Villegas, Sabrina Myers, and Priyanka Chaudhary. (Texas A&M AgriLife Research photo by Kathleen Phillips)

Student workers at the Texa A&M University Vegetable and Fruit Improvement Center for 2013 are (from the left, back row) Jose Perez, Michael Harris, Dennis Vandenberge, and (from the left, front row) Akshata Kulkarni, Natacha Villegas, Sabrina Myers, and Priyanka Chaudhary. (Texas A&M AgriLife Research photo by Kathleen Phillips)

Story by: Kathleen Phillips

COLLEGE STATION — Anyone familiar with a university town knows that many restaurants and retail stores revolve around college student employees, who may be learning life-long lessons in customer service while paying for their college education but who don’t plan to stay in those businesses.

Patients in physicians’ clinics and hospitals, however, may not realize that their medical treatments also likely had a student worker preparing samples and replicating trials in the laboratories of professors who maintain research projects alongside of academics. These students also say the lab jobs give life-long lessons but in areas they will use as they continue in their chosen careers.

Dennis Vandenberge had been working in a lab at Texas A&M University for about two weeks when the lead professor told him he would be presenting a paper about his job at a national conference later that month.

Vandenberge, a junior biology major from Stephenville, teamed up with fellow student worker Natacha Villegas, a senior from Venezuela, and developed a poster to explain how the various colors of watermelon flesh contain different phytochemicals that may help prevent cardiovascular disease and prostate cancer.

Two weeks later, the pair shared the $1,250 prize money for second place at the North American Agricultural Biotechnology Council’s 25th annual conference held at Texas A&M in June.

The money is helpful to offset studies, they agreed, but being able to explain their role in research is invaluable for their future plans. Their jobs are in a lab at the Vegetable and Fruit Improvement Center at Texas A&M where researchers are studying the healthy phytochemicals in watermelons, and both plan to attend medical school after earning bachelor’s degrees.

“Having an opportunity to do something like presenting a scientific poster about the research we work on is hugely beneficial to students,” Vandenberge said. “I wanted this job so that I could be in research. It’s important for undergraduates being involved that way.”

Villegas said their work in the watermelon research has given them insights that will be helpful in medical school in a few years.

“It was good for us to prepare the poster for competition because we got a better idea of the larger picture for the entire project,” said Villegas.

For Sabrina Myers of Abilene, word from her boss that she was going to present at the biotechnology conference came while she was on her honeymoon. She had a couple of days to prepare after returning before the judging began.

“Student workers focus more on doing an experiment over and over, so it is nice to see the full picture of what research you are working on,” said Myers, a senior whose work involved producing strawberries under high tunnels near Lubbock last summer. “One of the people at the conference asked me about the economic benefit of an extended growing season, so that was a good question to help me focus on what the research means to consumers.”

“In most jobs, a boss just might say ‘get it done.’ But being asked to present information about the work you do gives a student more pride in what they are doing,” said junior Michael Harris of Corpus Christi, who also works at the Vegetable and Fruit Improvement Center, purifying compounds that go into other research projects. “It’s good for undergraduates to know what’s important and to have judges ask questions and see that they care about our work.”

For some students, the “job” is a work in progress toward an advanced degree. A master’s or doctoral student’s job for which they receive a stipend also yields results about which a thesis or dissertation is written in order to graduate. Presenting information at conferences helps them learn even more about their work, several students noted.

“I felt very proud presenting my work to a number of important members of the agri-biotech community in North America, including scientists and representatives from the private sector, government and academia. It was a great opportunity to get feedback on my research,” said Jazmina Urriola of Panama, a doctoral student who earned the $1,500 prize at the biotechnology conference for her poster on research to improve nitrogen use efficiency in sorghum.

Urriola, who will graduate in August, said preparing for the competition enabled her to think about her work in a more creative way in an effort to attract viewers who may not otherwise know about the methods or purpose of her work.

“Often research presentations are useful to encounter from the audience different perspectives about the experiments I’m doing and receive constructive feedback,” said Julie Rothe from Amarillo, who is working on a doctoral degree in plant breeding.

Rothe’s job ultimately could benefit hungry people thousands of miles away from her well-equipped lab at the university. She’s seeking the genes that can enable cowpea to tolerate a lack of phosphorus in the soil.

“The soils of West Africa are poor in phosphorus, which is a vital soil macronutrient, and fertilizer costs for the area are exceedingly high,” she said. “The purpose of my research is to start breeding work for the development of cowpea lines that grow well in low phosphorus soils, because cowpea is a staple crop of West Africa.”

Rothe, who also presented at the biotechnology council’s student session, already has identified a few cowpeas that may qualify for breeding into new varieties.

“I did receive useful input from others about my research at the conference,” said Rothe, who picked up the $1,000 third place prize for her poster at the session. “And I learned about the most recent advances in agricultural biotechnology and the challenges ahead as agricultural biotechnology becomes more widespread.”

Doctoral student Jose Perez of McAllen, who at one point in his life didn’t think he would be able to continue in higher education, earned the $750 fourth place award for his poster about bitter melon, an Asian fruit that he thinks may one day provide a healthy addition to American and Mexican diets.

“This sort of exposure can draw attention and open doors,” Perez said. “And that could be helpful, because I’m trying to learn more about the healthful components of the bitter melon and how to introduce it here. In the Rio Grande Valley, there is a high rate of diabetes, and this melon could help with that disease.”

Indian master’s student Akshata Kulkarni said she gained confidence from her experience fielding questions from judges about her poster at the conference. Her work involves developing a more efficient method for measuring potency in onions, and her response to judges’ questions earned the $500 fifth place.

Another advantage for students who present their work in scientific competitions is the ability to think about their projects in a variety of categories, according to Priyanka Chaudhary of India, a doctoral student who has been working on a project to understand how phytochemicals in fruits and vegetables are affected by harvest and post-harvest handling.

“I’ve presented in horticulture contests before, but this one pertained to the biotechnology angle of the work. That made it a little harder, but also interesting,” said Chaudhary, who plans to return to India after graduation to start a health food business.

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How Circadian Rhythms Give Vegetables A Healthy Boost

vegetable in light

Story By: Allison Aubrey

Just as we have internal clocks that help regulate the systems in our bodies, fruit and vegetable plants have circadian rhythms, too.

And a new study published in Current Biology finds there may be a way to boost some of the beneficial compounds in plants by simulating the light-dark cycle after crops are harvested.

So, how does it work?

Well, take cruciferous vegetables such as cabbage, which contains cancer-fighting compounds called glucosinolates. Studies have shown that glucosinolates secrete enzymes that can remove carcinogens.

“The protective effect of these vegetables is that they rev up the capacity of cells to dispose of toxic compounds,” says Paul Talalay, a pharmacologist at Johns Hopkins University.

In other words, they help our bodies get rid of harmful substances.

Now, as vegetables go from the field to the store to our plate, the levels of these compounds start to fizzle out.

If you listen to my story on All Things Considered, you’ll hear how researcher Janet Braam of Rice University and her colleagues conducted lab studies to test the possibilities of coaxing more life — and more of these beneficial compounds — out of the fruits and vegetables we buy.

They put cabbages under light for 12 hours a day, followed by 12 hours of darkness, to try to re-create the light-dark cycle in the field.

Prior research has already shown that plants use circadian rhythms to help them judge when to turn on their chemical defenses. Some plants release these beneficial chemicals to fend off bugs in the field or cope with the stresses of heat or drought.

“And sure enough we found that when we put the plants under light-dark cycles, we found periods of accumulation of those [beneficial] chemicals,” explains Braam.

The peak of the compounds came in the afternoon, in the hours before dusk.

They were “significantly higher in the day,” Braam says — about twice as high. It was as if the plants were still alive, even though they’re no longer attached to their roots or the earth. “This very much surprised us,” Braam says.

Her team found similar responses with a range of crops including lettuce, spinach, sweet potatoes and blueberries.

Outside experts seem impressed by the study. “I’m excited to see this research going on,” plant researcher Bhimu Patil told me by phone. And he explains there’s a lot of interest in the industry in figuring out ways to retain the beneficial compounds in produce after harvest.

Braam is quick to point out that more research is needed to see whether the findings carry over into real-life situations, like our kitchens or in grocery stores. “It just opens the door to many possibilities,” says Braam.

For instance, it might make sense for supermarkets — or consumers at home — to think abut storing our produce under light-dark cycles.

Or maybe it’s time for a vegetable happy hour: eating our produce in the hours before dusk when some of the most beneficial compounds are at their peak.

 

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NABC25 Poster Presentation

Recently VFIC students, Priyanka Chaudhary, Akshata Kulkarni, Jose Perez, Michael Harris, Sabrina Myers, Natacha Villegas & DJ Vandenberge, participated in the poster contest at the North American Agricultural Biotechnology Council 25th Annual Conference.

All of our students did an excellent job and worked very hard preparing and presenting their posters. We are proud to announce that we had several award winners!

Second Place: DJ Vandenberge & Natacha Villegas
Impact of undergraduate students on biotechnology research at the Vegetable and Fruit Improvement Center, Texas A&M AgriLife Research

Fourth Place: Jose Perez
Bitter Melon (Momoridica charantia):A Potential  New Specialty Vegetable in Texas and its Anti-Diabetic Properties

Fifth Place: Akshata Kulkarni
Microplate reader: a rapid tool in onion breeding program to determine quality

 

The VFIC is on Facebook!

Vegetable & Fruit Improvement Center on Facebook

The VFIC is announcing a new format for our newsletter. In the past the newsletters were either printed or electronic, in order to give you frequent updates, we are implementing a Facebook newsletter.

 

This new format will continue to include lab updates, graduate student spotlight, new publications, conference announcements, awards of our faculty, staff and industry partners in addition to any other exciting news.  A link to the corresponding VFIC webpage will be included in the post so you can see more detailed information.

 

To receive these updates, simply click on the link below and like our Facebook page if you haven’t already. The updates will then show up in your newsfeed as they’re posted or you can check our page to see what’s going on.

 

This will allow you to interact with us with ease. Please feel free to comment on posts and ask questions. We would love to hear from you and are excited about this new venture!

 

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David Byrne Receives National 2013 Carroll R. Miller Award for Peach Research

 

Dr. David Byrne, Texas A&M AgriLife Research peach breeder, examines trees in his plot in College Station. (Texas A&M AgriLife Research photo by Kathleen Phillips)

Dr. David Byrne, Texas A&M AgriLife Research peach breeder, examines trees in his plot in College Station. (Texas A&M AgriLife Research photo by Kathleen Phillips)

COLLEGE STATION — Dr. David Byrne, Texas A&M AgriLife Research scientist in College Station, has received the Carroll R. Miller Award from the National Peach Council.

The award was established in memory of Miller of Martinsburg, W.V., a founding member and first president of the peach council, according to the group’s website. The award is given “to encourage and recognize noteworthy research relating to improved marketing and utilization of peaches and/or peach products.”

Byrne, who researches stone fruit and roses, was cited for his recent introduction of four new peach varieties suitable for growing in areas that do not receive the cold temperatures that most other peach varieties need to produce.

He said they are the first series low-acid white peaches for warmer climates.

“These releases are part of several decade-long projects in which I’ve been developing a range of stone fruit types adapted to the warm winter regions of the world,” Byrne said.

He is currently in the process of releasing a series of yellow peaches, nectarines and flat peaches adapted for such regions. He has also actively investigated the origin of peach germplasm and, with various collaborators, has documented the health benefits of eating peaches and plums.

Byrne received his bachelor’s in plant science from Rutgers University in 1975 and his doctorate in plant breeding in 1980 from Cornell University.

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Story by Kathleen Phillips, ka-phillips@tamu.edu